4.

Factors associated with recurrence-free survival

Factors	Univariate			Multiple regression
	HR (95% CI)	P		HR (95% CI)	P
Age (years)	0.632 (0.427, 0.936)	0.022		0.548 (0.348, 0.862)	0.009
< 65	89
≥ 65	94
Gender	1.512 (1.008, 2.267)	0.046		–	–
Male	128
Female	55
Differentiation	0.719 (0.428, 1.325)	0.312		–	–
Well/moderately	152
Poorly	31
Comorbidities	0.732 (0.495, 1.083)	0.118		–	–
Yes	108
No	75
Tumor size (cm)	1.916 (1.121, 3.274)	0.659		–	–
< 3	121
≥ 3	62
Tumor number	1.317 (0.835, 2.078)	0.236		–	–
Single	147
Multiple	36
Adjacent to large vessels	0.154 (0.870, 2.418)	0.046		–	–
Yes	153
No	30
DAA therapy	0.431 (0.211, 0.791)	0.003		0.392 (0.276, 0.836)	0.023
Yes	88
No	95
α-fetoprotein level (ng/mL)	1.884 (1.271, 2.793)	0.002		1.760 (1.148, 2.698)	0.002
≤ 20	118
> 20	65
GGT (U/L)	1.418 (0.962, 1.712)	0.381		–	–
≤50	77
>50	106
Albumin level (g/L))	0.781 (0.518, 1.177)	0.238		–	–
< 35	50
≥ 35	131
Total bilirubin level (μmol/L)	0.948 (0.583, 1.542)	0.829		–	–
< 20.5	150
≥ 20.5	33
ALT level (U/L)	0.936 (0.640, 1.368)	0.731		–	–
< 40	89
≥ 40	94
AST level (U/L)	0.893 (0.596, 1.336)	0.581		–	–
< 40	60
≥ 40	123
Platelet count (109)	0.868 (0.592, 1.271)	0.466		–	–
< 100	99
≥ 100	84
Prothrombin time international normalized ratio	1.022 (0.682, 1.532)	0.915		–	–
< 1.1	117
≥ 1.1	66
Procedure session	1.877 (1.010, 3.488)	0.046		–	–
1	162
> 1	21
Child–Pugh score	1.345 (0.493, 3.665)	0.563		–	–
A	175
B	8
ALBI grade	1.398 (0.950, 2.058)	0.089		–	–
1	95
2, 3	88
Data in parentheses are 95% confidence intervals. ALBI, albumin- bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyl transferase.