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. 2019 Nov;16(4):771–783. doi: 10.20892/j.issn.2095-3941.2019.0050

2.

(A and B) H446 and H82 cells were infected with shILF2 or scrambled shRNAs. Then, glucose uptake and lactate production were measured over the subsequent 36 h. (C-F) Extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) were assessed in H446 and H82 cells infected with shILF2 or scrambled shRNAs. (G and H) Glycolysis, glycolytic capacity, glycolytic reserve, basal respiration and maximal respiration in H446 and H82 cells were compared using data from Panels C-F. (I and J) H446 and H82 cells were infected with ILF2-overexpressing or vector control lentivirus. Then, glucose uptake and lactate production were measured over the next 36 h. (K-P) Extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) were assessed in H446 and H82 cells infected with ILF2-overexpressing or vector control lentivirus. (O and P) Glycolysis, glycolytic capacity, glycolytic reserve, basal respiration and maximal respiration of H446 and H82 cells were compared using data from Panels K-N. *, <italic>P</italic> &lt; 0.05, * *, <italic>P</italic> &lt; 0.01.

ILF2 enhances OXPHOS and suppresses aerobic glycolysis in SCLC cells.