. 2019 Aug 27;160(11):2646–2662. doi: 10.1210/en.2019-00493

Table 1.

Effect of Maternal LPS and (+)-Naloxone Treatment on Body Morphometry (Absolute Weight) in Male and Female Progeny at 20 wk

Absolute Weight	PBS	(+)-Naloxone	LPS	LPS/(+)-Naloxone
Male progeny
N, pups (dams)	24 (10)	21 (7)	14 (5)	25 (7)
Total body weight, g^*	25.0 ± 0.5^a	27.5 ± 0.6^b	26.6 ± 0.8^a,b	25.9 ± 0.6^a
Lean body weight, g	24.4 ± 0.4^a	27.1 ± 0.4^b	24.9 ± 0.5^a	25.6 ± 0.4^a,b
Total muscle, mg^§	748 ± 19^a,b	831 ± 20^c	692 ± 25^b	817 ± 20^a,c
Total central fat, mg^{^}	734 ± 34^a	902 ± 36^b	864 ± 46^a,b	840 ± 37^a,b
Muscle/central fat ratio	1.05 ± 0.04^a	0.95 ± 0.04^a,b	0.84 ± 0.06^b	1.00 ± 0.05^a,b
Quadriceps, mg^#	325 ± 9^a	365 ± 10^b	277 ± 12^c	358 ± 10^a,b
Triceps, mg^#	195 ± 6^a,b	218 ± 7^a	188 ± 8^b	216 ± 7^a,b
Biceps, mg^#	31.7 ± 2.7	29.5 ± 2.9	34.2 ± 3.7	29.3 ± 3.0
Gastrocnemius muscle, mg	197 ± 7	218 ± 8	193 ± 10	215 ± 8.0
Retroperitoneal fat, mg	405 ± 21^a	498 ± 23^b	420 ± 29^a,b	434 ± 23^a,b
Perirenal fat, mg	53.4 ± 4.7^a	69.8 ± 6.4^a,b	70.5 ± 5.1^a,b	72.7 ± 5.2^b
Epididymal fat, mg	276 ± 18^a	334 ± 19^a,b	374 ± 24^b	333 ± 19^a,b
Female progeny
N, pups (dams)	21 (10)	8 (5)	9 (4)	13 (7)
Total body weight, g^*	21.9 ± 0.5	22.8 ± 0.7	21.4 ± 0.8	21.7 ± 0.6
Lean body weight, g	21.0 ± 3.8	22.0 ± 6.2	20.3 ± 5.8	20.7 ± 0.5
Total muscle, mg^§	587 ± 15^a,b	661 ± 24^a	541 ± 23^b	608 ± 20^a,b
Total central fat, mg^{^}	716 ± 34	618 ± 55	650 ± 52	628 ± 45
Muscle/central fat ratio	0.87 ± 0.05	1.13 ± 0.09	0.88 ± 0.08	0.99 ± 0.07
Quadriceps, mg^#	252 ± 8^a,b	293 ± 13^a	231 ± 12^b	261 ± 11^a,b
Triceps, mg^#	149 ± 5^a	164 ± 7^a	122 ± 7^b	156 ± 6^a
Biceps, mg^#	25.6 ± 1.6	25.9 ± 2.7	29.8 ± 2.5	25.5 ± 2.2
Gastrocnemius muscle, mg	162 ± 7	179 ± 11.4	158 ± 11	166 ± 9
Retroperitoneal fat, mg	388 ± 14	396 ± 23.1	359 ± 22	375 ± 19
Perirenal fat, mg	39.2 ± 2.9	42.4 ± 4.4	32.5 ± 4.7	39.8 ± 3.9
Parametrial fat, mg	288 ± 26	190 ± 42	249 ± 39	213 ± 34

Different superscript letters (a, b, and c) indicate differences between treatment groups (P < 0.05). The number of progeny in each group is indicated, with the number of pregnant dams in parentheses. Other organs are shown in an online repository (46).

Data are estimated marginal mean ± SEM absolute weights in 20-wk-old male and female progeny of dams administered LPS and/or (+)-naloxone in late gestation. Effect of treatment group was analyzed by mixed model linear repeated measures ANOVA, using dam as subject and litter size as covariate.

^{^§}

Total muscle is the sum of all muscles measured.

^{^}

Total central fat is the sum of all fat depots measured.

^{^#}

Combined weight of left and right organs.