. 2019 Aug 27;160(11):2646–2662. doi: 10.1210/en.2019-00493

Table 4.

Effect of Fetal Sex and (+)-Naloxone Treatment on Cytokine Expression in Fetal and Gestational Tissues, Without LPS Administration

	Sex^a	(+)-Naloxone^a	Sex–(+)-Naloxone Interaction^a	PBS		PBS + Naloxone
	Sex^a	(+)-Naloxone^a	Sex–(+)-Naloxone Interaction^a	Male	Female	Male	Female
Placenta (n)				12	4	4	12
IL-1A	NS	NS	NS	0.91 ± 0.16	1.26 ± 0.30	0.92 ± 0.09	0.95 ± 0.10
IL-1B	NS	NS	NS	0.74 ± 0.12	1.77 ± 1.10	1.05 ± 0.08	1.07 ± 0.27
IL-6	NS	NS	NS	0.93 ± 0.21	1.29 ± 0.15	0.57 ± 0.06	1.45 ± 0.45
TNF	0.028	NS	NS	0.84 ± 0.09	1.48 ± 0.44	0.62 ± 0.03	1.23 ± 0.27
IL-10	NS	NS	NS	1.11 ± 0.26	0.66 ± 0.16	1.44 ± 0.78	1.38 ± 0.56
Fetal membrane (n)				12	4	4	12
IL-1A	NS	NS	NS	1.01 ± 0.12	0.95 ± 0.21	0.68 ± 0.12	1.37 ± 0.49
IL-1B	NS	NS	NS	0.84 ± 0.14	1.49 ± 0.59	1.31 ± 0.07	1.04 ± 0.25
IL-6	NS	NS	NS	0.99 ± 0.26	1.03 ± 0.56	0.93 ± 0.20	1.43 ± 0.21
TNF	NS	NS	0.101	1.15 ± 0.40	0.56 ± 0.27	0.25 ± 0.09	1.14 ± 0.27
IL-10	NS	NS	NS	0.79 ± 0.17	1.64 ± 0.61	1.14 ± 0.56	1.35 ± 0.63
Fetal brain (n)				12	4	4	12
IL-1A	NS	NS	0.060	1.16 ± 0.18	0.52 ± 0.14	0.82 ± 0.24	1.26 ± 0.23
IL-1B	NS	0.045	0.091	1.07 ± 0.12	0.80 ± 0.30	1.15 ± 0.12	1.75 ± 0.24
IL-6	NS	0.078	0.053	1.06 ± 0.11	0.82 ± 0.22	1.01 ± 0.31	1.88 ± 0.26
TNF	NS	NS	NS	1.08 ± 0.14	0.75 ± 0.15	1.07 ± 0.16	1.27 ± 0.11
IL-10	NS	NS	NS	1.01 ± 0.18	0.99 ± 0.26	0.99 ± 0.05	1.68 ± 0.23
Decidua (n)				12	4	4	12
IL-1A	NS	NS	NS	1.06 ± 0.26	0.82 ± 0.18	0.57 ± 0.08	1.06 ± 0.17
IL-1B	NS	NS	NS	0.96 ± 0.19	1.12 ± 0.31	1.09 ± 0.41	2.06 ± 0.98
IL-6	NS	NS	0.004	0.80 ± 0.16	1.59 ± 0.45	2.24 ± 0.95	0.88 ± 0.13
TNF	NS	NS	NS	0.96 ± 0.07	1.11 ± 0.19	0.99 ± 0.19	1.67 ± 0.32
IL-10	NS	NS	NS	0.85 ± 0.20	1.43 ± 0.29	0.97 ± 0.42	1.49 ± 0.52
PTGS2	NS	NS	NS	1.04 ± 0.22	0.87 ± 0.23	0.81 ± 0.09	0.99 ± 0.11
Myometrium (n)				12	4	4	12
IL-1A	NS	NS	0.072	1.03 ± 0.14	0.90 ± 0.19	0.32 ± 0.11	1.17 ± 0.26
IL-1B	NS	NS	NS	1.17 ± 0.30	0.50 ± 0.06	0.39 ± 0.09	1.67 ± 0.83
IL-6	NS	NS	NS	1.16 ± 0.27	0.51 ± 0.03	1.29 ± 0.38	1.18 ± 0.34
TNF	0.051	NS	NS	0.79 ± 0.33	1.62 ± 0.79	0.30 ± 0.12	1.41 ± 0.34
IL-10	NS	NS	NS	0.95 ± 0.18	1.16 ± 0.46	1.53 ± 0.34	1.74 ± 0.63
PTGS2	NS	NS	NS	1.18 ± 0.28	0.46 ± 0.06	1.20 ± 0.39	1.42 ± 0.15

Abbreviation: NS, not significant.

^{^a}

Effects of sex, (+)-naloxone, and sex–(+)-naloxone interaction were determined by linear mixed model analysis, and P values are reported when P < 0.10.