Table 2.

Pooled HRs for incident diabetes association with prediabetes status at baseline and Harrell’s C-statistics for predicting 5-year risk of diabetes associated with prediabetes status at baseline

Prediabetes definition	Multiple adjusted*
	N	HR (95% CI)†	I2 (%)	C-statistics (95% CI)†	I2 (%)
WHO-FPG‡	73 151	5.54 (4.31 to 7.12)	93.9	0.789 (0.772 to 0.807)	63.5
ADA-FPG‡	73 151	4.17 (3.36 to 5.17)	93.3	0.803 (0.787 to 0.819)	62.2
2hPG	12 846	3.78 (3.11 to 4.60)	66.4	0.793 (0.774 to 0.812)	0
ADA-HbA1c	19 375	7.81 (4.32 to 14.14)	94.9	0.811 (0.724 to 0.899)	97.9
IEC-HbA1c	19 375	8.36 (4.88 to 14.33)	93.9	0.802 (0.729 to 0.874)	96.2

*Age, sex, body mass index, systolic blood pressure, smoking and family history of diabetes.

†Normal (non-prediabetes or diabetes) was the reference group, see table 1 for the respective definitions.

‡Family history of diabetes was not adjusted for MESA and Aichi.

ADA, American Diabetes Association; FPG, fasting plasma glucose; HbA1c, glycated hemoglobin; 2hPG, 2-hour postload plasma glucose; IEC, International Expert Committee.