Table 1.
The impact of glycemic traits on breast cancer risk in Breast Cancer Association Consortium using Mendelian randomization
| All SNPs | Inverse variance weighting with multiplicative random effects | MR-Egger | Weighted median | ||||||
| OR | 95% CI | I2 | OR | 95% CI | Intercept | Intercept p value |
OR | 95% CI | |
| Glucose (mmol/L) (n=21) | 1.03 | 0.85 to 1.25 | 0.763 | 1.02 | 0.66 to 1.57 | 0.001 | 0.94 | 0.99 | 0.85 to 1.14 |
| HbA1c (%) (n=32) | 1.02 | 0.73 to 1.45 | 0.843 | 1.23 | 0.64 to 2.37 | −0.004 | 0.53 | 1.07 | 0.86 to 1.33 |
| Type 2 diabetes (n=147) | 0.98 | 0.95 to 1.01 | 0.707 | 1.01 | 0.95 to 1.08 | −0.003 | 0.24 | 1.02 | 0.99 to 1.06 |
| Excluding pleiotropic SNPs | |||||||||
| Glucose (mmol/L) (n=11) | 1.00 | 0.81 to 1.23 | 0.72 | 1.09 | 0.69 to 1.71 | −0.004 | 0.68 | 0.94 | 0.81 to 1.10 |
| HbA1c (%) (n=19) | 1.06 | 0.91 to 1.23 | 0.00 | 1.12 | 0.85 to 1.49 | −0.002 | 0.62 | 1.06 | 0.85 to 1.32 |
| Type 2 diabetes (n=108) | 0.97 | 0.94 to 1.01 | 0.585 | 0.90 | 0.80 to 1.01 | 0.005 | 0.18 | 0.97 | 0.93 to 1.01 |
SNP, single-nucleotide polymorphism.