Table 4.

The impact of glycemic traits on prostate cancer risk in Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome consortium using Mendelian randomization

All SNPs	Inverse variance weighting with multiplicative random effects			MR-Egger				Weighted median
	OR	95% CI	I2	OR	95% CI	Intercept	Intercept p value	OR	95% CI
Glucose (mmol/L) (n=11)	0.93	0.73 to 1.17	0.464	0.73	0.41 to 1.29	0.008	0.38	0.88	0.70 to 1.12
HbA1c (%) (n=19)	0.90	0.58 to 1.40	0.575	1.26	0.32 to 4.92	−0.005	0.62	1.03	0.65 to 1.63
Type 2 diabetes (n=112)	1.02	0.97 to 1.07	0.690	0.98	0.86 to 1.10	0.003	0.50	0.97	0.93 to 1.02
Excluding pleiotropic SNPs*
Glucose (mmol/L) (n=10)	1.01	0.81 to 1.24	0.263	0.75	0.48 to 1.19	0.01	0.20	0.90	0.72 to 1.13
Type 2 diabetes (n=111)	1.02	0.97 to 1.07	0.686	0.98	0.87 to 1.11	0.003	0.48	0.98	0.93 to 1.03

*No pleiotropic SNPs identified for HbA1c.

SNP, single-nucleotide polymorphism.