Fig. 4.

ZY4 inhibits P. aeruginosa lung infection and inflammation in vivo. (A) Following intranasal inoculation of mice (n = 8) with P. aeruginosa C1 and subsequent i.v. administration of ZY4 or colistin (CS) to examine their therapeutic effects, bacteria load in lung homogenate is shown. (B) Representative histopathological images of processed lung section with hematoxylin and eosin (H&E) staining. Images are presented at a magnification of 40×. (C) The number of counted infiltrated inflammatory cells within processed lung sections from B. Data represent the mean ± SD of 8 individual experiments. *P < 0.05, **P < 0.01.