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. 2019 Dec 16;116(52):26516–26522. doi: 10.1073/pnas.1909585117

Fig. 5.

Fig. 5.

ZY4 suppresses dissemination of bacteria to target organs. (A–D) ZY4 suppresses dissemination of P. aeruginosa to target organs. Mice (n = 10) were i.p. injected with P. aeruginosa C1, followed by i.p injection of ZY4 (10 mg/kg), colistin (10 mg/kg), levofloxacin (100 mg/kg), or vehicle (PBS). Bacterial burden was determined in the blood (A), liver (B), spleen (C), and kidney (D). (E–I) ZY4 inhibits cytokine release in LPS shock mice model. Mice (n = 8) were i.p. injected with LPS (15 mg/kg) or PBS (control), followed by i.p. injection of ZY4 (10 mg/kg) or PBS 30 min after LPS injection. Levels of IL-10 (E), IFN-γ (F), TNF-α (G), MCP-1 (H), and IL-6 (I) in plasma were determined 6 and 18 h after LPS injection, respectively. (J–M) ZY4 suppresses dissemination of A. baumannii to target organs. A. baumannii was i.p. injected into female C57BL/6 mice (n = 8); 1 h after the injection, ZY4 (1, 2, 4 mg/kg), colistin (1 mg/kg), and vehicle (PBS) were i.p. applied. Bacterial burdens in blood (J), lung (K), liver (L), and spleen (M) are shown. NC, normal healthy mice. Data represent the mean ± SD of 8 individual experiments. *P < 0.05, **P < 0.01.