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. 2019 Dec 9;116(52):26900–26908. doi: 10.1073/pnas.1914704116

Fig. 1.

Fig. 1.

Relative body weight, temperature change, serum viral RNA copy number, and survival of aged ferrets infected with recombinant SFTS viruses. (A–D) Twelve ferrets in each group were inoculated with 4 × 106 PFUs of rHB29 (red), 4 × 106 PFUs of rHB29NSsP102A (blue), 5 × 105 PFUs of rHB2912aaNSs (green), or 5 × 105 PFUs of CB8/2016 (purple). Relative weight (A), temperature (B), viral RNA copy number in the serum (C), and survival (D) were assessed at the indicated times p.i., and mean values are shown ± SEM. The asterisks indicate significance compared to each day p.i. sample analyzed by one-way ANOVA with Dunnett multiple comparison test (A–C) or the 2-tailed Mantel–Cox method (D). *P = 0.0424, **P = 0.0023 and ***P < 0.0134 (A); *P = 0.0007, **P < 0.0001, ***P = 0.0113 and ****P = 0.0032 (B); *P = 0.0031, **P = 0.0192, ***P = 0.0214, ****P = 0.0378, *****P = 0.0001, and ******P < 0.0001, (C); and *P < 0.0001 (D). # Sample not tested as animals had died/been killed.