Table 3.
ORs (95% CIs) for tertiles of activin A per clinical characteristics and laboratory tests in combined cohorts with diabetes
| Logistic regression table | Overall diabetes cohort (n=206) | |||
| Unadjusted variables | Medium vs low tertile | High vs low tertile | ||
| Unadjusted OR (95% CI) | P value | Unadjusted OR (95% CI) | P value | |
| eGFR calculations | ||||
| CKD-EPI eGFR, per 10 mL/min/1.73 m2 | 0.73 (0.63 to 0.85) | <0.0001 | 0.47 (0.37 to 0.59) | <0.0001 |
| MDRD eGFR, per 10 mL/min/1.73 m2 | 0.79 (0.69 to 0.90) | 0.0004 | 0.44 (0.34 to 0.57) | <0.0001 |
| Clinical features and laboratory measurements | ||||
| Age, per 10 years | 1.98 (1.37 to 2.85) | 0.0003 | 1.94 (1.36 to 2.77) | 0.0003 |
| BMI, kg/m2 | 1.03 (0.97 to 1.10) | 0.4 | 1.08 (1.01 to 1.15) | 0.02 |
| Hemoglobin, g/L | 0.96 (0.94 to 0.99) | 0.003 | 0.94 (0.91 to 0.96) | <0.0001 |
| Hemoglobin A1c, % | 0.92 (0.72 to 1.17) | 0.5 | 1.13 (0.88 to 1.46) | 0.3 |
| Albumin, per 0.01 g/dL | 0.98 (0.96 to 0.99) | 0.001 | 0.96 (0.95 to 0.97) | <0.0001 |
| Sodium, mmol/L | 1.09 (0.96 to 1.24) | 0.2 | 1.11 (0.98 to 1.25) | 0.08 |
| BUN, mg/dL | 1.09 (1.04 to 1.14) | 0.0001 | 1.17 (1.11 to 1.23) | <0.0001 |
| PTH, per 10 pg/mL | 1.02 (1.004 to 1.04) | 0.01 | 1.05 (1.03 to 1.07) | <0.0001 |
| UACR, mg/g | 1.004 (1.001 to 1.01) | 0.008 | 1.007 (1.0 to 1.01) | 0.001 |
| Log UACR, per log | 1.49 (1.18 to 1.87) | 0.001 | 2.04 (1.60 to 2.61) | <0.0001 |
| CRP, mg/L | 1.03 (0.96 to 1.09) | 0.4 | 1.001 (0.93 to 1.07) | 0.9 |
| Log CRP, per log | 0.95 (0.84 to 1.07) | 0.4 | 0.86 (0.77 to 0.95) | 0.004 |
| eGFR-adjusted variables* | ||||
| Clinical features and laboratory measurements | ||||
| Age, per 10 years | 1.48 (0.99 to 2.22) | 0.06 | 1.08 (0.67 to 1.75) | 0.8 |
| BMI, per kg/m2 | 1.05 (0.98 to 1.12) | 0.1 | 1.08 (0.98 to 1.18) | 0.1 |
| Hemoglobin, per g/L | 0.98 (0.95 to 1.003) | 0.08 | 0.96 (0.93 to 0.99) | 0.02 |
| Albumin, per 0.01 g/dL | 0.98 (0.96 to 0.99) | 0.03 | 0.98 (0.96 to 0.99) | 0.003 |
| BUN, per mg/dL | 1.04 (0.98 to 1.12) | 0.2 | 1.04 (0.98 to 1.11) | 0.2 |
| PTH, per 10 pg/mL | 1.01 (0.99 to 1.02) | 0.5 | 1.02 (1.002 to 1.04) | 0.03 |
| Log UACR, per log | 1.42 (1.12 to 1.81) | 0.004 | 1.56 (1.16 to 2.09) | 0.03 |
NGSP hemoglobin A1c converter http://www.ngsp.org/convert1.asp may be used to calculate hemoglobin A1c values from % to mmol/mol. Values represent mean (SD) or number (%).
P-values with bold font represent statistically significant values (<0.05).
*All variables adjusted for CKD-EPI eGFR including age, sex, race and serum creatinine.
BMI, body mass index; BUN, blood urea nitrogen; CKD, chronic kidney disease; CRP, C reactive protein; eGFR, estimated glomerular filtration rate; MDRD, modification of diet renal disease; PTH, parathyroid hormone; UACR, urine albumin-to-creatinine ratio.