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. 2019 Dec 16;116(52):26717–26726. doi: 10.1073/pnas.1915043116

Fig. 2.

Fig. 2.

FLO1 treatment in SAMP mice with established disease results in amelioration of ileitis. (A) Timeline indicating experimental design. (B) Histologic analysis (reported as total inflammatory scores), as well as (C) IL-1α and IL-1β protein levels and (D) MPO activity in involved and uninvolved areas of ileal mucosa from both FLO1- and Dex-treated SAMP mice compared to (vehicle-treated) controls. (E) Representative images of full-thickness H&E-stained ileal tissues from the 3 experimental groups show decreased cellular infiltration (red arrows), preservation of epithelial cell integrity (black arrows), and diminished thickening of the muscularis mucosa (blue arrows) in both FLO1- and Dex-treated mice vs. controls. (Scale bar: 200 µm.) Data are representative of 2 independent experiments and presented as median ± interquartile range. In B, statistical analysis was determined by Kruskal–Wallis followed by Dunn’s post hoc tests, n = 10–11; **P = 0.001 and *P = 0.016. In C and D, statistical analysis was determined by 1-way ANOVA followed by Tukey’s post hoc test, n = 11–17; ****P < 0.0001, **P ≤ 0.005, and *P ≤ 0.049.