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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Bioorg Med Chem Lett. 2019 Aug 20;29(19):126633. doi: 10.1016/j.bmcl.2019.126633

Figure 3. Comparison of the effects of the ω-hydroxyl triazole bisphosphonate 15 and the HA-conjugate 27 on protein geranylgeranylation.

Figure 3.

RPMI-8226 (R) or MM.1S (M) cells were incubated for 48 hours in the presence or absence of lovastatin (Lov, 10 μM) or varying concentrations of the test compounds (for the HA-conjugate 27, concentration is based on the percent weight of the inhibitor in the HA polymer conjugate). Immunoblot analysis of uRap1a (antibody detects only unmodified protein) and β-tubulin (as a loading control). These blots are representative of three independent experiments.