Table 1.
In vivo recovery for microdialysis probes measured by retrodialysis prior to drug administration for each probe in the three tissue sites
| Tissue | Mean recovery (CV) | ||
|---|---|---|---|
| Cisplatin | Carboplatin | Oxaliplatin | |
| Vein | 0.75 (14%) | 0.79 (17%) | 0.82 (7%) |
| Muscle | 0.57 (20%) | 0.45a (28%) | 0.50 (12%) |
| Brain | 0.46 (5%) | 0.30b (19%) | 0.34 (30%) |
Recovery is expressed as mean (coefficient of variation) for three animals
a
Recovery for one muscle microdialysis probe was excluded due to technical problems with flow, therefore, n = 2. Recovery for the individual probes was 0.36 and 0.54
b
Recovery from four individual probes (data from one animal with two probes inserted, data from a single probe in two animals)