Table 2.

Platinum AUC_0–4h in plasma UF and CSF from standard sampling methods and in vein, muscle, and brain using microdialysis sampling for the platinum analogs cisplatin, carboplatin, and oxaliplatin

	Animal	Dose (mg/kg)	AUC0–4h (μM h)
			Plasma UF	Vein	Muscle	CSFa	Brain
Cisplatin	T68	2	14	13	12	0.69 (V)	NDb
	R842	10	92	112	72	4.0 (S)	1.1
	B9884	10	89	89	103	4.8 (V)	2.8
Carboplatin	V29	10	84	109	59	4.2 (V)	3.4
	RQ1357	10	136	131	NAc	2.0 (L)	3.9
	G4	10	118	133	153	1.6 (V)	4.1
Oxaliplatin	HH351	25	144	196	119	0.4 (L)	4.3
	9SL	23	133	146	94	0.4 (L)	2.0
	R829	21	112	107	110	0.9 (L)	8.6

^aLetter in parentheses denotes CSF sampling site: V ventricular CSF from Ommaya reservoir, S subarachnoid CSF from the vertex, L CSF from a lumbar catheter

^bND platinum was not detectable in dialysate

^cNA not analyzed due to technical problems with flow rate that precluded calculation of in vivo recovery and measurement of tissue concentration