Table 3.

Penetration of the platinum analogs into the CNS (CSF standard sampling or brain measured using microdialysis) expressed as a percentage of drug systemic exposure (AUC in plasma UF by standard sampling or vein by microdialysis)

	${\text{AUC}}_{0-4\text{h}}^{\text{CNS}}:{\text{AUC}}_{0-4\text{h}}^{\text{Blood}}(\%)$
	CSF:Plasma UF	Brain:Vein
Cisplatin	4.4, 5.4a	1.0, 3.1a
Carboplatin	1.5 (1.4–5.0)	3.1 (3.0–3.1)
Oxaliplatin	0.3 (0.3–0.8)	2.2 (1.4–8.0)

Values represent the median (range)

^aData from two animals receiving the 10 mg/kg dose