Table 1:

Comparison between nucleophilic aromatic substitutions using 6-fluoro-9-(2-Deoxy-β-D-erythro-pentofuranosyl)purine (for the synthesis of dA adducts 7a and 7b) or 2-fluoro-O⁶-(2-p-nitrophenylethyl)-2’-deoxyinosine (for the synthesis of dG adducts 9a [20] and 9b [19])

Coupling product	yield	Time (RT)
7a (R, α, dA adduct)	81%	2d
7b (S, β, dA adduct)	75%	4d
9a[20] (R, α, dG adduct)	60%	2 weeks
9b[19] (S, β, dG adduct)	54%	3 weeks