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Selective conditions for the deprotection of the 2-(trimethylsilyl)ethoxycarbonyl (teoc) group with or without concomitant decarbamoylation.
| Starting Material | Reagent | Equivalent | Time | Products (yield) |
|---|---|---|---|---|
| 7a 0.6M | TAS-F or TBAF, 3 M | 5 | 5 h | 5a (63%) |
| 7a 0.095M | TBAF, 0.47 M | 5 | 15 h | 4a (68%) |
| 7b 0.091 M | TBAF, 0.47 M | 5.2 | 4 h | 5b (63%) |
| 7b 0.028 M | TAS-F, 0.37 M | 14 | 24 h | 4b (82%) |
