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. Author manuscript; available in PMC: 2019 Dec 30.
Published in final edited form as: Sci Transl Med. 2017 May 31;9(392):eaaf6295. doi: 10.1126/scitranslmed.aaf6295

Fig. 6.

Fig. 6.

C3-deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. A. NeuN IR in hippocampal CA3, CA1 and DG and PFC in APP/PS1 and APP/PS1;C3 KO mice. Scale bar: 50 μm. B. APP/PS1;C3 KO mice had more neurons in hippocampal CA3 compared to APP/PS1 mice (*p < 0.05, unpaired t-test). C-E. No significant differences were observed in neuron numbers in CA1, DG and PFC between APP/PS1 and APP/PS1;C3 KO mice. F. Age-dependent neuron loss was observed in WT and APP/PS1 mice from P30 to 16 months of age, and in APP/PS1 mice from 4 months to 16 months of age, but not in C3 KO or APP/PS1;C3 KO mice. (* p < 0.05, ** p < 0.01; n=6–8; 6 equidistant planes 150 μm apart, two-way ANOVA and Bonferroni post-hoc test).