Table 6. The correlation of THADA rs13429458,TOX3 rs4784165, and HMGA2 rs2272046 with PCOS subgroups.
SNPs | Gene | Subgroup | Genotype | PCOS subgroup frequency | p-value |
rs13429458 | THADA | OA+PCOM | A/A | 12 (48%) | 0.009** |
(n=25) | A/C | 12 (48%) | |||
C/C | 1 (2%) | ||||
rs4784165 | TOX3 | OA+PCOM | G/G | 6 (24%) | 0.028* |
(n=25) | G/T | 5 (20%) | |||
T/T | 14 (56%) | ||||
rs2272046 | HMGA2 | HA+OA | A/A | 5 (83.3%) | 0.043* |
(n=6) | A/C | 1 (16.7%) | |||
C/C | 0 (0%) | ||||
p-values were calculated by chi-squared test. *p-values < 0.05, **p-values < 0.01. HA: hyper androgenism; OA: Oligo/amenorrhea; PCOM: polycystic ovarian morphology. |