Fig. 6.

Average mutant allele frequency (MAF) for a given mutation vs. N(t), the number of cells at the time it is formed, for the stochastic model with the infinite-sites assumption (26, 32) (blue), the deterministic model with the infinite-sites assumption (22) (red), and without the infinite-sites assumption (gold; this manuscript). The deterministic model with the infinite-sites assumption leads to a reciprocal relationship between N(t) and the average MAF and a straight line with a slope of −1 on a log–log plot. The deterministic model without infinite sites has an asymptotic limit for the MAF of k_mut-eff for N(t) comparable to 1/k_mut-eff and larger. Parameters are b = 0.25/d, d = 0.18/d, and k_mut-eff = 6.1 × 10⁻⁷.