Table 1.
Probability of emergence of multiply resistant cells
| No. of cells (N) | No. resistant loci (R) | Therapies (K) | PNSCR |
| 109 | 1 | 2 | 0.999 |
| 109 | 100 | 2 | 6.5 × 10−3 |
| 109 | 100 | 3 | >0.999 |
| 1011 | 100 | 3 | 0.965 |
| 1012 | 1 | 2 | 0.604 |
| 1012 | 100 | 3 | 0.699 |
Probability PNSCR that no cell in a cancer of N total cells will be mutationally resistant to all of K non–cross-resistant therapies, where in each case there are R neutral single bases in the genome, mutation of which confers resistance in selected scenarios. See SI Appendix, Table S5, for additional scenarios.