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. 2019 Dec 23;116(52):26230–26238. doi: 10.1073/pnas.1903671116

Fig. 5.

Fig. 5.

(A) High levels of PKA activity phosphorylate ryanodine receptors (pS2808RyR2) on the SER and cause calcium leak into the cytosol. (B) pS2808RyR2 can be seen on the elaborated SER under a glutamate synapse in layer II EHC from a middle-aged monkey (9 y). Orange arrowheads depict pS2808RyR2 labeling, black arrows delineate a synapse. mit = mitochondrion; Den = dendrite; Ax = axon. Reprinted from ref. 7, with permission from Elsevier. (Scale bar: 200 nm.)