Table I.
Baseline and histological characteristics of testicular tissues collected from nine (pre) pubertal patients.
| Organ culture code | Age (years) | Diagnosis | Testicular histology before culture | |||
|---|---|---|---|---|---|---|
| Most advanced germ cell | Average Johnsen score # | AMH expression | AR expression | |||
| OCID22* | 6 | Rhabdomyosarcoma | Spermatogonia | 2.6 | Yes | No |
| OCID30 | 8.5 | Intracranial, spinal embryonal tumor | Spermatogonia | 2.7 | Yes | No |
| OCID25 | 9 | Lymphocytic leukemia | Spermatogonia | 2.4 | Yes | No |
| OCID23 | 10 | Rhabdomyosarcoma | Spermatogonia | 2.3 | Yes | Dim |
| OCID24 | 10 | Glioma | Spermatogonia | 2.9 | Yes | No |
| OCID27 | 10.5 | Anaplastic Large Cell Lymphoma | Spermatogonia | 2.9 | Yes | No |
| OCID29 * | 11 | Rhabdomyosarcoma | Few spermatogonia (<25%) | 2.2 | Yes | No |
| OCID26 * | 12 | Intracranial, spinal embryonal tumor | Few spermatogonia (<25%) | 2.2 | Yes | No |
| OCID28 | 14 | M. Hodgkin | Elongating spermatids | 6.0 | No | Moderate |
*Testicular histological characteristics evaluated in cryopreserved-thawed tissue.
#Calculation of average Johnsen score (Johnsen, 1970) is described in Supplementary Table SI.