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. 2019 Dec 10;34(12):2495–2512. doi: 10.1093/humrep/dez205

Figure 4.

Figure 4

FSH responses to KP-54 in the three preclinical rat models of PCOS. Profiles of serum FSH responses to KP-54 administration are presented from the three preclinical models of PCOS (PNA, NeNA and PWA) at adulthood. The animals were injected for 11 days with a daily bolus of KP-54 (100 μg/kg; N = 10 per PCOS model) or 0.9% saline (N = 10 per model), and serial blood sampling was conducted on Days 1, 4, 7 and 11 of treatment, just before (0) or at the indicated time intervals after s.c. KP-54 injection. Androgenized animals from each PCOS model, injected with vehicle, were run in parallel for comparative purposes. In addition, the profiles of LH responses to a single bolus of KP-54 or vehicle in control (non-androgenized) female rats are also shown in the left panels. Data are presented as the mean ± SEM.