Skip to main content
. 2019 Dec 30;14(12):e0227091. doi: 10.1371/journal.pone.0227091

Table 4. Asthma medication use for latent class phenotypes.

Early transient wheeze
n (%)
Current wheeze/ asthma
n (%)
Mild asthma
n (%)
Moderate asthma
n (%)
Any current asthma medication 4 (3.9) 4 (11.1) 37 (56.1) 61 (81.3)
RR 1.5 (1.1, 1.9)b
β2 short- acting medication more than twice in the last week 2 (2.0) 2 (5.6) 10 (15.2) 26 (35.6)
RR 2.4 (1.2, 4.9)a
Any regular preventer medication in the last 12 months 0 (0) 0 (0) 17 (28.8) 29 (40.9)
RR 1.6 (1.0, 2.5)a
Any periodic preventer medication in the last 12 months 3 (3.0) 5 (13.9) 21 (36.8) 38 (58.5)
RR 1.7 (1.1, 2.5)b
Regular ICS medication in the last 12 months 0 (0) 0 (0) 9 (15.8) 13 (20.6)
1.8 (0.8, 3.7)
Periodic ICS medication in the last 12 months 1 (1.0) 4 (11.4) 17 (29.8) 30 (47.6)
RR 1.7 (1.1, 2.7)a
Regular β2 ICS combination medication in the last 12 months 0 (0) 0 (0) 11 (19.3) 19 (28.8)
RR 1.6 (0.8, 3.3)
Periodic β2 ICS combination medication in the last 12 months 2 (2.0) 2 (5.7) 5 (8.8) 8 (12.1)
RR 1.6 (0.6, 4.4)
Regular β2 long-acting medication in the last 12 months 0 (0) 0 (0) 2 (3.6) 5 (8.6)
RR 2.5 (0.6, 9.9)
Periodic β2 long-acting medication in the last 12 months 2 (2.0) 1 (2.9) 7 (12.7) 9 (15.5)
RR 1.3 (0.5, 3.3)
Regular LTRA medication in the last 12 months 0 (0) 0 (0) 6 (10.5) 5 (8.2)
RR 0.8 (0.2, 2.7)
Periodic LTRA medication in the last 12 months 1 (1.0) 0 (0) 5 (8.8) 4 (6.6)
RR 0.7 (0.2, 3.3)
Systemic corticosteroid in the last 12 months 1 (1.0) 3 (8.8) 3 (5.4) 3 (5.2)
R 1.0 (0.2, 4.6)

a p <0.05,

b p< 0.001,

Relative risks (RR) and 95% confidence intervals shown for Moderate asthma versus Mild asthma.