Table 5. Respiratory function of latent class phenotypes.
Healthy mean ± SD |
Early transient wheeze mean ± SD |
Current wheeze/asthma mean ± SD |
Mild asthma mean ± SD |
Moderate asthma mean ± SD |
|
---|---|---|---|---|---|
FENO (parts per billion) n = 705 | 16.04± 13.61 | 15.73± 14.18 β -0.31 (-3.47, 2.86) |
15.76± 17.57 β -0.28 (-6.21, 5.65) |
22.09± 20.77 β 6.05 (0.88, 11.22)a |
27.18± 22.21 β 11.14 (5.52, 16.77)c |
PreFEV1 z score n = 576 |
-0.40± 0.97 |
-0.76± 0.91 β-0.36 (-0.61, -0.12)b |
-0.67± 1.11 β -0.27 (-0.69, 0.15) |
-0.72± 0.89 β -0.32 (-0.62, -0.02)a |
-0.78± 1.04 β-0.38 (-0.68, -0.08)a |
PreFVC z score n = 576 |
-0.26± 0.99 | -0.39± 0.88 β -0.13 (-0.36, 0.11) |
-0.26± 0.92 β 0.01 (-0.35, 0.36) |
-0.12± 0.91 β 0.15 (-0.17, 0.46) |
-0.26± 0.97 β 0.01 (-0.27, 0.28) |
PreFEV1FVC z score ratio n = 576 |
-0.23± 1.02 |
-0.62± 1.10 β -0.39 (-0.69, -0.09)a |
-0.70± 1.08 β -0.47 (-0.86, -0.07)a |
-0.96± 1.05 β -0.72 (-1.08, -0.037)c |
-0.81± 1.15 β -0.58 (-0.92, -0.24)b |
PostFEV1 z score n = 588 |
-0.18± 0.97 |
-0.46± 0.86 β -0.29 (-0.53, -0.06)a |
-0.31± 0.98 β -0.14 (-0.50, 0.22) |
-0.27± 0.89 β -0.10 (-0.38, 0.18) |
-0.40± 1.04 β -0.23 (-0.52, 0.07) |
PostFVC z score n = 588 |
-0.24± 0.91 | -0.36± 0.84 β -0.11 (-0.33, 0.11) |
-0.29± 0.90 β -0.04 (-0.37, 0.28) |
-0.18± 0.88 β 0.06 (-0.23, 0.35) |
-0.28± 1.04 β -0.03 (-0.32, 0.25) |
PostFEV1FVC z score ratio n = 588 |
0.10± 0.97 |
-0.17±1.07 β -0.28 (-0.55, 0.00)a |
-0.07± 1.14 β -0.17 (-0.58, 0.25) |
-0.18±0.94 β -0.28 (-0.56, 0.00)a |
-0.18±1.05 β -0.28 (-0.58, 0.02) |
Reversibility (%) n = 478 |
2.58± 5.01 |
4.87± 5.14 β 2.29 (0.89, 3.69)b |
4.73± 5.77 β 2.14 (-0.11, 4.40) |
4.09± 3.95 β 1.51 (0.16, 2.85)a |
5.36± 6.78 β 2.77 (0.75, 4.80)b |
a p <0.05,
b p< 0.001,
c p<0.0001,
**some missing data due to not all completing spirometry
Beta coefficients and 95% confidence intervals compared to healthy phenotypes. N = 705**