Table 1. Differentially expressed genes in neurons at 24 hours post injection in the intracortical kainic acid model of mTLE.
| Differentially expressed genes in neurons | |||
|---|---|---|---|
| Upregulated genes (N = 135) | |||
| Gene symbol | logFC | FDR | Gene description |
| Acan | 3,94 | 0,000 | aggrecan |
| Sdc1 | 3,60 | 0,001 | syndecan 1 |
| Inhba | 4,12 | 0,001 | inhibin beta-A |
| Socs3 | 4,21 | 0,001 | suppressor of cytokine signaling 3 |
| Timp1 | 5,38 | 0,007 | tissue inhibitor of metalloproteinase 1 |
| Megf11 | 2,25 | 0,011 | multiple EGF-like-domains 11 |
| Nptx2 | 3,61 | 0,011 | neuronal pentraxin 2 |
| Hspa1a | 5,46 | 0,011 | heat shock protein 1A |
| Fgl2 | 3,07 | 0,011 | fibrinogen-like protein 2 |
| Col27a1 | 3,22 | 0,012 | collagen, type XXVII, alpha 1 |
| Mapk4 | 2,28 | 0,012 | mitogen-activated protein kinase 4 |
| Cd1d1 | 2,94 | 0,018 | CD1d1 antigen |
| Sik1 | 2,31 | 0,019 | salt inducible kinase 1 |
| Hspa1b | 4,82 | 0,019 | heat shock protein 1B |
| Tnc | 2,08 | 0,019 | tenascin C |
| Ptgs2 | 3,11 | 0,019 | prostaglandin-endoperoxide synthase 2 |
| Gipr | 3,72 | 0,019 | gastric inhibitory polypeptide receptor |
| Trib1 | 2,46 | 0,019 | tribbles pseudokinase 1 |
| Tpbg | 2,10 | 0,019 | trophoblast glycoprotein |
| Lhfp | 1,71 | 0,019 | lipoma HMGIC fusion partner |
| Fosb | 3,32 | 0,019 | FBJ osteosarcoma oncogene B |
| Arc | 2,40 | 0,020 | activity regulated cytoskeletal-associated protein |
| Fosl2 | 2,26 | 0,020 | fos-like antigen 2 |
| Gadd45g | 2,54 | 0,027 | growth arrest and DNA-damage-inducible 45 gamma |
| Pcdh11x | 2,26 | 0,027 | protocadherin 11 X-linked |
| Pmepa1 | 2,30 | 0,027 | prostate transmembrane protein, androgen induced 1 |
| Stk40 | 2,03 | 0,027 | serine/threonine kinase 40 |
| Pde6b | 2,91 | 0,027 | phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide |
| Wisp1 | 2,09 | 0,027 | WNT1-inducible-signaling pathway protein 1 |
| 9330188P03Rik | 3,35 | 0,027 | RIKEN cDNA 9330188P03 gene |
| Pappa | 2,89 | 0,027 | pregnancy-associated plasma protein A |
| Hspb1 | 4,00 | 0,027 | heat shock protein 1 |
| Atf3 | 4,52 | 0,029 | activating transcription factor 3 |
| Tll1 | 3,71 | 0,029 | tolloid-like |
| Sulf1 | 1,57 | 0,031 | sulfatase 1 |
| Lbh | 3,01 | 0,034 | limb-bud and heart |
| Nedd9 | 1,51 | 0,035 | neural precursor cell expressed, developmentally down-regulated gene 9 |
| Parp3 | 2,93 | 0,035 | poly (ADP-ribose) polymerase family, member 3 |
| Rrad | 4,89 | 0,035 | Ras-related associated with diabetes |
| Trh | 6,22 | 0,035 | thyrotropin releasing hormone |
| 4931440P22Rik | 1,70 | 0,037 | RIKEN cDNA 4931440P22 gene |
| Cyr61 | 2,90 | 0,037 | Cysteine-rich angiogenic inducer 61 |
| Fos | 2,89 | 0,037 | FBJ osteosarcoma oncogene |
| Cgref1 | 2,08 | 0,037 | cell growth regulator with EF hand domain 1 |
| Angptl4 | 2,49 | 0,037 | angiopoietin-like 4 |
| Srxn1 | 2,09 | 0,037 | sulfiredoxin 1 homolog (S. cerevisiae) |
| Vim | 2,84 | 0,039 | vimentin |
| Vgf | 2,37 | 0,041 | VGF nerve growth factor inducible |
| Plpp4 | 2,33 | 0,043 | phospholipid phosphatase 4 |
| Clcf1 | 3,01 | 0,045 | cardiotrophin-like cytokine factor 1 |
| Zbtb46 | 1,58 | 0,048 | zinc finger and BTB domain containing 46 |
| Egr2 | 2,18 | 0,052 | early growth response 2 |
| Bach1 | 1,72 | 0,052 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 |
| Samd4 | 1,90 | 0,052 | sterile alpha motif domain containing 4 |
| Rgs4 | 2,24 | 0,053 | regulator of G-protein signaling 4 |
| Cdkn1a | 2,86 | 0,053 | cyclin-dependent kinase inhibitor 1A (P21) |
| Adra1a | 1,92 | 0,054 | adrenergic receptor, alpha 1a |
| Csrnp1 | 2,36 | 0,054 | cysteine-serine-rich nuclear protein 1 |
| Gal | 3,64 | 0,054 | galanin and GMAP prepropeptide |
| Npas4 | 3,24 | 0,055 | neuronal PAS domain protein 4 |
| Sbno2 | 2,21 | 0,055 | strawberry notch 2 |
| Fndc9 | 3,19 | 0,061 | fibronectin type III domain containing 9 |
| Syndig1l | 1,94 | 0,063 | synapse differentiation inducing 1 like |
| Gpr3 | 1,97 | 0,075 | G-protein coupled receptor 3 |
| Fam129b | 1,40 | 0,075 | family with sequence similarity 129, member B |
| Sv2c | 2,56 | 0,075 | synaptic vesicle glycoprotein 2c |
| Adam19 | 1,62 | 0,081 | a disintegrin and metallopeptidase domain 19 (meltrin beta) |
| Pim1 | 2,43 | 0,083 | proviral integration site 1 |
| Bag3 | 1,81 | 0,083 | BCL2-associated athanogene 3 |
| Sphk1 | 2,57 | 0,086 | sphingosine kinase 1 |
| Mapkapk3 | 1,97 | 0,086 | mitogen-activated protein kinase-activated protein kinase 3 |
| Zfp36 | 2,50 | 0,086 | zinc finger protein 36 |
| Cdh4 | 1,45 | 0,087 | cadherin 4 |
| Kdm6b | 1,57 | 0,090 | KDM1 lysine (K)-specific demethylase 6B |
| Emp1 | 2,49 | 0,091 | epithelial membrane protein 1 |
| Spp1 | 3,14 | 0,091 | secreted phosphoprotein 1 |
| Sorcs3 | 2,28 | 0,094 | sortilin-related VPS10 domain containing receptor 3 |
| Cd1d2 | 3,29 | 0,097 | CD1d2 antigen |
| Prex1 | 2,06 | 0,101 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 |
| Pros1 | 2,10 | 0,101 | protein S (alpha) |
| Uck2 | 1,35 | 0,101 | uridine-cytidine kinase 2 |
| Plce1 | 1,40 | 0,101 | phospholipase C, epsilon 1 |
| Tgfb1i1 | 1,66 | 0,101 | transforming growth factor beta 1 induced transcript 1 |
| Crispld2 | 2,18 | 0,117 | cysteine-rich secretory protein LCCL domain containing 2 |
| Frrs1 | 1,87 | 0,117 | ferric-chelate reductase 1 |
| Blnk | 2,81 | 0,118 | B cell linker |
| 1700071M16Rik | 1,68 | 0,119 | RIKEN cDNA 1700071M16 gene |
| Rgs20 | 1,74 | 0,119 | regulator of G-protein signaling 20 |
| Ier2 | 2,17 | 0,120 | immediate early response 2 |
| Itprip | 1,88 | 0,130 | inositol 1,4,5-triphosphate receptor interacting protein |
| Smad7 | 1,83 | 0,130 | SMAD family member 7 |
| Svil | 1,52 | 0,130 | supervillin |
| Serinc2 | 1,79 | 0,136 | serine incorporator 2 |
| Cemip2 | 1,44 | 0,154 | cell migration inducing hyaluronidase 2 |
| Mir132 | 3,39 | 0,154 | microRNA 132 |
| Pear1 | 3,01 | 0,164 | platelet endothelial aggregation receptor 1 |
| Zdhhc22 | 1,85 | 0,167 | zinc finger, DHHC-type containing 22 |
| Medag | 2,23 | 0,167 | mesenteric estrogen dependent adipogenesis |
| Amotl1 | 1,71 | 0,175 | angiomotin-like 1 |
| Serpina3i | 2,75 | 0,178 | serine (or cysteine) peptidase inhibitor, clade A, member 3I |
| Ptgs1 | 2,01 | 0,178 | prostaglandin-endoperoxide synthase 1 |
| Ifit1 | 2,33 | 0,178 | interferon-induced protein with tetratricopeptide repeats 1 |
| Kcnip3 | 1,67 | 0,178 | Kv channel interacting protein 3, calsenilin |
| Odc1 | 1,57 | 0,178 | ornithine decarboxylase, structural 1 |
| Igsf9b | 2,27 | 0,178 | immunoglobulin superfamily, member 9B |
| Homer1 | 1,49 | 0,179 | homer scaffolding protein 1 |
| Spred1 | 1,62 | 0,184 | sprouty protein with EVH-1 domain 1, related sequence |
| Samd11 | 2,19 | 0,186 | sterile alpha motif domain containing 11 |
| Cdk18 | 1,98 | 0,186 | cyclin-dependent kinase 18 |
| Scd4 | 2,01 | 0,191 | stearoyl-coenzyme A desaturase 4 |
| Dgat2l6 | 3,15 | 0,191 | diacylglycerol O-acyltransferase 2-like 6 |
| Dusp4 | 1,88 | 0,191 | dual specificity phosphatase 4 |
| Anxa2 | 2,12 | 0,191 | annexin A2 |
| Serpina3n | 1,85 | 0,191 | serine (or cysteine) peptidase inhibitor, clade A, member 3N |
| Tspan9 | 1,68 | 0,191 | tetraspanin 9 |
| Eva1b | 2,00 | 0,191 | eva-1 homolog B (C. elegans) |
| Btc | 2,40 | 0,191 | betacellulin, epidermal growth factor family member |
| Acvr1c | 1,91 | 0,193 | activin A receptor, type IC |
| Rara | 1,54 | 0,194 | retinoic acid receptor, alpha |
| St8sia2 | 2,11 | 0,195 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 |
| Tm4sf1 | 2,49 | 0,195 | transmembrane 4 superfamily member 1 |
| Cdh22 | 1,77 | 0,195 | cadherin 22 |
| Gfra1 | 1,50 | 0,202 | glial cell line derived neurotrophic factor family receptor alpha 1 |
| Itga5 | 2,11 | 0,205 | integrin alpha 5 (fibronectin receptor alpha) |
| C2cd4b | 2,11 | 0,206 | C2 calcium-dependent domain containing 4B |
| Rasa4 | 1,84 | 0,220 | RAS p21 protein activator 4 |
| Mapk6 | 1,51 | 0,223 | mitogen-activated protein kinase 6 |
| Egr4 | 1,91 | 0,227 | early growth response 4 |
| Itpkc | 1,84 | 0,227 | inositol 1,4,5-trisphosphate 3-kinase C |
| Ptx3 | 2,72 | 0,235 | pentraxin related gene |
| Tnfrsf12a | 1,87 | 0,235 | tumor necrosis factor receptor superfamily, member 12a |
| Drd1 | 1,82 | 0,246 | dopamine receptor D1 |
| Downregulated genes (N = 15) | |||
| Gene symbol | logFC | FDR | Gene description |
| Cxcl12 | -1,96 | 0,027 | chemokine (C-X-C motif) ligand 12 |
| Ogn | -2,71 | 0,029 | osteoglycin |
| Plk5 | -2,79 | 0,040 | polo like kinase 5 |
| Cys1 | -1,85 | 0,041 | cystin 1 |
| Capn3 | -2,14 | 0,052 | calpain 3 |
| Echdc2 | -1,77 | 0,079 | enoyl Coenzyme A hydratase domain containing 2 |
| Cyp7b1 | -2,28 | 0,097 | cytochrome P450, family 7, subfamily b, polypeptide 1 |
| Gm12216 | -1,65 | 0,101 | predicted gene 12216 |
| Gstm6 | -1,57 | 0,161 | glutathione S-transferase, mu 6 |
| Cd34 | -1,63 | 0,167 | CD34 antigen |
| Stxbp6 | -1,51 | 0,186 | syntaxin binding protein 6 (amisyn) |
| Crlf1 | -1,97 | 0,194 | cytokine receptor-like factor 1 |
| Macrod1 | -1,52 | 0,195 | MACRO domain containing 1 |
| Gm35339 | -1,43 | 0,195 | predicted gene, 35339 |
| 6330420H09Rik | -2,15 | 0,216 | RIKEN cDNA 6330420H09 gene |
Differentially expressed genes in neurons (FDR < 0.25); logFC = log fold change; FDR = false discovery rate.