Table 3. Relevant GO and KEGG terms of up- and downregulated genes in neurons at 24 hours post injection in the intracortical kainic acid model of mTLE.
| Upregulated genes in neurons (N = 135) | Downregulated genes in neurons (N = 15) | |
|---|---|---|
| GO* | • Cell differentiation | • Lymphocyte migration |
| Signal transduction | • Leukocyte migration | |
| • Cell death | • Endothelial cell proliferation | |
| • Regulation of gene expression | • Regeneration | |
| • Cell-cell signaling | • Cellular response to DNA damage stimulus | |
| • Cell surface receptor signaling | • Growth factor activity | |
| • Cell growth | • Vesicle organization | |
| KEGG* | • ECM-receptor interaction | |
| • MAPK signaling | ||
| • IL17 signaling | ||
| • cAMP signaling | ||
| • TNF signaling | ||
| • VEGF signaling | ||
| • TGFbeta signaling |
Relevant GO and KEGG terms associated with significantly (FDR 0.25) upregulated genes
* = p<0.05.