Table 4. Relevant GO and KEGG terms of up- and downregulated genes in glia at 24 hours post injection in the intracortical kainic acid model of mTLE.
| Upregulated genes in glia (N = 147) | Downregulated genes in glia (N = 85) | |
|---|---|---|
| GO* | • Regulation of IL1 | • Purinergic nucleotide receptor activity |
| • Response to IL1 | • Regulation of ion transport | |
| • MAPK | • PLC activating G-protein receptor | |
| • Apoptotic process | • NAD binding | |
| • Lymphocyte chemotaxis | • Glutamate receptor signaling | |
| • Cytokine production | • Myelin sheath | |
| • Angiogenesis | • Mitochondrial part | |
| KEGG* | • ECM-receptor interaction | • Glutathione metabolism |
| • MAPK signaling | • Pyruvate metabolism | |
| • PI3K-Akt signaling pathway | • ABC transporters | |
| • Cytokine-cytokine receptor interaction | • cAMP signaling pathway | |
| • TNF signaling | • Glycine, serine and threonine metabolism | |
| • VEGF signaling | ||
| • JAK-stat signaling |
Relevant GO and KEGG terms associated with significantly (FDR 0.25) upregulated genes
* = p<0.05.