Figure 3.

Lesion development and parasite load in L. amazonensis-infected BALB/c mice. Mice were infected with L. amazonensis promastigotes (2 × 10⁶) and treated with either anti-PD-1 or anti-PD-L1 MoAbs (100 μg/dose), administered twice a week intraperitoneally, beginning at 7 days post-infection, for 56 days. (A) Lesion size and (B) parasite load from individually mice (5 mice/group) are presented as data ± SEM of a representative experiment out of two independent one producing the same profile. **p < 0.01, ***p < 0.001(Anova (A)). ***p < 0.0001 (T Test (B)).