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. 2019 Dec 30;9:20362. doi: 10.1038/s41598-019-56994-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation between serum IP-10 levels and IFN-related gene activation. (a) ATIV recipients were stratified into ‘early responders’ or ‘non-responders’ with respect to the presence or absence of early (Day [D]1) enrichment in the IFN signatures. Serum IP-10 levels categorized by responder status are presented for the ATIV and placebo groups. (b) Eigengene plot showing the correlation between the eigengene of the ‘Interferon’ blood transcriptional module (BTM) DC.M5.12²⁰ and the expression of IP-10 in the ATIV group at D0 and D1. Eigengene (as defined previously⁴⁵) of a set of genes is calculated based on the expression of all genes in a gene set (BTM) and is correlated with the expression of the majority of the genes in the BTM. Pearson’s r = 0.81; p < 1e-6.