Table 2.
Characteristics of the Study Population.
| LDLR-null group (n = 32) |
LDLR-defective group (n = 35) |
p Value between two groups |
|
|---|---|---|---|
| Demographic Characteristics | |||
| N | 32 | 35 | |
| Age, years | 48.69 ± 14.36 | 51.97 ± 15.47 | 0.37 |
| Men, n (%) | 18 (56.3) | 19 (54.3) | 0.61 |
| Body mass index, kg/m2 | 25.21 ± 3.34 | 25.38 ± 3.79 | 0.84 |
| ASCVD, n (%) | 12 (37.5) | 9 (25.7) | 0.33 |
| Glucose Values | |||
| FPG, mg/dL | 85.7 ± 6.84 | 88.11 ± 6.32 | 0.14 |
| HbA1c, % | 5.42 ± 0.29 | 5.51 ± 0.28 | 0.25 |
| Lipid Values | |||
| Total cholesterol, mg/dL | 188.65 ± 25.26 | 186.5 ± 24.31 | 0.86 |
| HDL cholesterol, mg/dL | 49.16 ± 10.62 | 52.81 ± 8.84 | 0.07 |
| Triglycerides, mg/dL | 87 (80–117) | 88.5 (81–119) | 0.76 |
| LDL cholesterol, mg/dL | 121.54 ± 21.46 | 116.33 ± 20.48 | 0.31 |
| Non-HDL cholesterol, mg/dL | 140.48 ± 22.04 | 135.69 ± 22.07 | 0.16 |
| ApoB, mg/dL | 116.79 ± 25.02 | 110.53 ± 24.71 | 0.11 |
| ApoAI, m g/dL | 133.71 ± 23.34 | 137.62 ± 23.31 | 0.29 |
| ApoB to ApoAI ratio | 0.88 ± 0.34 | 0.81 ± 0.31 | 0.06 |
| Lp(a), nmol/L | 20.8 (10.05–62.95) | 19.2 (9.69–41.05) | 0.45 |
| Risk Factors | |||
| Systolic BP, mmHg | 118.55 ± 9.33 | 119.17 ± 13.37 | 0.83 |
| Diastolic BP, mmHg | 70.48 ± 7.78 | 71.36 ± 9.17 | 0.28 |
| Smoking, n (%) | 10 (31.3) | 13 (37.1) | 0.61 |
| hs-CRP, mg/dL | 0.10 (0.05–0.19) | 0.09 (0.04–0.15) | 0.39 |
| Treatment | |||
| Duration of Statin therapy, years | 9.5 (2.5–17.5) | 8 (1.5–12) | <0.05 |
| Ezetimibe, n (%) | 21 (65.6) | 14 (40.0) | <0.05 |
| Antihypertensive therapy, n(%) | 11 (34.4) | 13 (37.1) | 0.81 |
| Intensity of Statin Therapy | |||
| Low, n (%) | — | — | — |
| Moderate, n (%) | 8 (25.0) | 25 (71.4) | <0.05 |
| High, n (%) | 24 (75.0) | 10 (28.6) | <0.05 |
| Early atherosclerotic biomarker | |||
| PWV, m/s | 9.58 ± 0.92 | 7.41 ± 0.83 | <0.05 |
Data are presented as mean ± standard deviation, percentages, or median (interquartile range).
ASCVD = atherosclerotic cardiovascular disease, FPG = fasting plasma glucose, HbA1c = glycated hemoglobin, HDL = high-density lipoprotein, LDL = low-density lipoprotein, LDLR = low-density lipoprotein receptor, ApoB = apolipoprotein B, ApoAI = apolipoprotein AI, Lp(a) = lipoprotein (a), BP = blood pressure, hs-CRP = high sensitivity C-reactive protein, PWV = pulse wave velocity.