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. 2019 Dec 30;9:20324. doi: 10.1038/s41598-019-56832-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heat Maps of the Abundant Bacterial OTUs. Heat Maps of the Abundant Bacterial OTUs. (A). Heat map of the abundant fecal bacterial OTUs from the genotype-microbiota mouse groups at Day 0 (before Pac was administered). Values in the cells are relative abundances of the bacteria, and only those OTUs with greater than 2% average relative abundance are shown. (B) Heat map of the Pac-induced differences in the abundant fecal bacterial OTUs from the genotype-microbiota mouse groups. Values in the cells are the differences in mean relative abundances of the bacteria where: V-P = Veh minus Pac and D0-10 = Pac at D0 minus Pac at D10. Heat maps were clustered on both axes. Number of replicates for each genotype-microbiota group are shown in Fig. 7. Bacterial taxa abbreviations are: Porphyro, Porphyromonadaceae; Clostridium, Clostridium aerotolerans; Akkerman, Akkermansia muciniphila; Alistipes, Alistipes onderdonkii; Barnes, Barnesiella; and the numbers following the underscores indicate the OTU numbers.