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. 2019 Dec 30;9:20329. doi: 10.1038/s41598-019-56861-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of oral administration of KAG-308 in surgically induced mouse knee osteoarthritis (OA). (a) Schematic representation of the surgical procedure for OA induction, oral administrations, and time of sacrifice. Oral treatments were performed once a day from the day after surgery for 8 wks. Quantification of OA development using the Osteoarthritis Research Society International (OARSI) score for (b) the first experiment (n = 5 in the vehicle group and n = 4 in the KAG-308 group) and (c) the follow-up experiment as a confirmatory phase (n = 13 in the vehicle group and n = 12 in the KAG-308 group). Symbols represent individual mice; long and short bars show the mean and SD, respectively. *P < 0.005 by Welch’s t test. (d) Representative safranin-O staining from vehicle and 3 mg/kg KAG-308 groups. Scale bar, 100 µm.