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. 2019 Dec 30;9:20329. doi: 10.1038/s41598-019-56861-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of oral KAG-308 treatment on synovial tissues in surgically induced mouse knee OA. (a) Representative hematoxylin and eosin (HE) staining of sagittal knee sections from each experimental group 2 wks after OA induction. Inset boxes in the top panels indicate the regions of the bottom panels. Scale bar, 200 µm. (b) Quantification of synovial inflammation in each experimental group (n = 6 in the sham and n = 8 per group in the OA model). Symbols represent individual mice; long and short bars show the mean and SD, respectively. *P < 0.05, **P < 0.005 by ANOVA followed by Tukey’s post hoc test.