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. 2019 Dec 30;9:20301. doi: 10.1038/s41598-019-56748-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RNF183 expression in the dextran sulfate sodium (DSS)-induced colitis mouse model. (a) Changes in body weight and (b) colon length between the control (water) and DSS-treated mice after 5 days exposure. Asterisks represent significant differences (n = 6; Student’s t-test, *p < 0.05). (c) Haematoxylin-eosin (HE) staining of mouse colon tissue exposed to control (water) and 3.5% DSS for 5 days ( × 20 magnification). (d) Expression of RNF183 and RNF186 mRNA in whole colon tissues between control and 3.5% DSS-treated mice at 5 days. (e) The mRNA levels of inflammatory markers in whole colon tissues between control and 3.5% DSS-treated mice at 5 days. The expression levels were determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR) Asterisks represent significant differences (n = 6; paired t-test, *p < 0.05, **p < 0.01, ***p < 0.001).