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. 2019 Dec 30;9:20289. doi: 10.1038/s41598-019-56827-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ceftriaxone and Corticosterone induce opposite displacements in S1 state maps. (a) No significant differences were found between groups in ΔRatio1. (b) A significant increase was found in ΔRatio2 corticosterone injection (Cort), a significant decrease was found after ceftriaxone injection (Cef), and no significant difference was present when both ceftriaxone and corticosterone were injected (Cef + Cort). (c) Average displacement vectors representing the changes in ΔRatio1 and ΔRatio2 for each group. The Cef group presented a clear decrease in ΔRatio2. Error bars indicate Mean ± SEM, n.s. indicates non-significant. *indicates P < 0.05; ***indicates P < 0.001.