Skip to main content
. 2019 Aug 16;12(2-3):77–94. doi: 10.1007/s12307-019-00229-x

Table 1.

Kinin receptors in glioblastoma and other types of cells: Potential functionality in cancer progression

Target Cell type Kinin receptor expression Associated function References
B1 receptor C6 Mouse glioma B1R expression and activity Cell migration by COX and AP-1 activation [89]
B1 receptor Human microglia B1R upregulation in response to activation Cell motility and chemotaxis of BK-induced microglial migration is mediated by B1R but not by B2R [105]
B2 receptor D54 human GBM Receptor expression not verified Glioma invasion is stimulated by DBK to amoeboid type of migration [136]
B1 receptor U87 human GBM B1R expression stimulated by bradykinin Increase in 3D cell invasion after co-culture with MSCs [21, 100]
B1 and B2 receptor U138 and U251 human GBM Endogenous expression of both B1R and B2R Both B1R and B2R are involved in glioma cell proliferation [94]
B1 and B2 Receptors PC3 prostate cancer Endogenous expression of both B1R and B2R B1R and B2R activation is required for the proliferation of androgen-independent prostate cancer cells [137]
B1R- carboxipeptidase M (CPM) heterodimers HEK human embryonic kidney B1R activity and CPM expression CPM and B1 receptor mediates BK or KD stimulation of B1R signalling, independent of the enzymatic activity of CPM [138]
B1R-CPM heterodimers HEK human embryonic kidney B1R and B2R activity and CPM expression CPM expression is required to generate a B1R-dependent [Ca2+]i increase by kallidin or bradykinin [139]
B2 receptor Adipose–derived human MSCs (ADSCs) B1R and B2R endogenous expression BK induced α-Smooth Muscle Actin expression in hADSCs by TGF-β1-Smad2 signalling pathway [111]
B2 receptor 3 T3 fibroblasts B2R endogenous expression and activity Bradykinin promotes formation of peripheral actin microspikes and filopodia in fibroblasts [140]