Table 2.

Top 20 most commonly prescribed QTc-prolonging medications in the study cohort from 3- months prior to diagnosis up to and including date of diagnosis

QT-prolonging medication	Medication category	TdP risk Classification	Rate of Usage *(%)
Azithromycin	Antimicrobial	Known	4.5
Citalopram	Psychiatric	Known	4.3
Moxifloxacin	Antimicrobial	Known	3.4
Vardenafil	Erectile dysfunction	Possible	2.7
Ciprofloxacin	Antimicrobial	Known	2.6
Levofloxacin	Antimicrobial	Known	2.4
Mirtazapine	Psychiatric	Possible	2.3
Ondansetron	Antiemetic	Known	2.1
Gatifloxacin	Antimicrobial	Known	1.4
Venlafaxine	Psychiatric	Possible	1.3
Promethazine	Antiemetic	Possible	1.3
Donepezil	Psychiatric	Known	1.1
Amiodarone	Cardiovascular	Known	1
Risperidone	Psychiatric	Possible	0.9
Methadone	Analgesic	Known	0.7
Cilostazol	Cardiovascular	Known	0.7
Nortriptyline	Psychiatric	Possible	0.6
Fluconazole	Antimicrobial	Known	0.5
Clarithromycin	Antimicrobial	Known	0.4
Chloroquine	Antirheumatict†	Known	0.4

^*3 months prior to or at Cohort Entry Date

^†Less commonly prescribed as an anYmicrobial for prevenYon or treatment of malaria