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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Leuk Res. 2019 Nov 6;88:106268. doi: 10.1016/j.leukres.2019.106268

Figure 4.

Figure 4.

Variable selection for AML cases and controls using (A) multivariate linear regression [Model (1)], (B) lasso logistic regression on bootstrapped data, and (C) random forest. (A) Volcano plot showing the case/control fold-change and the corresponding nominal p-value from Model (1) for each adduct. The dotted line represents a nominal p-value of 0.05. (B) Adducts ranked by the proportion of times each adduct was selected by bootstrap lasso out of 500 iterations. (C) The top 20 adducts ranked by random forest variable importance (i.e., mean decrease in Gini index).