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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2019 Oct 31;1867(2):118570. doi: 10.1016/j.bbamcr.2019.118570

Figure 2. RAS family members.

Figure 2.

RAS proteins were aligned with Clustal multiple alignment. KRAS4A and KRAS4B are derived from alternative splicing of the same gene resulting in different C-termini. Grey shading highlights residues that are identical in all four RAS proteins. RAS proteins can be divided into three functional regions: the effector lobe, allosteric lobe, and hypervariable region (HVR). SW1, switch 1 region (aa 30–40); SW2, switch 2 region (aa 60–76); Mg2+/N, magnesium and nucleotide binding regions, *, farnesylation site; , mutation hotspots; P, phosphorylation site; #, ubiquitylation or acetylation sites; +, nitrosylation site; x, Ca2+ binding sites. Alpha helices (α) and beta sheets (β) are indicated below lineup.