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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2019 Oct 31;1867(2):118570. doi: 10.1016/j.bbamcr.2019.118570

Figure 5. Biologics targeting RAS.

Figure 5.

A. Structure of NS1 monobody bound to HRAS WT (PDB:5E95). B. Structure of DARPin K13 bound to KRAS(G12V):GDP (PDB: 6H46). Both structures are shown in the same orientation to illustrate the different regions targeted by NS1 versus K13. Coloring of figure is the same as in Fig. 4. Both NS1 and K13 target the allosteric lobe of RAS.