Table 1.

Summary statistics for the genome-wide significant association of single nucleotide polymorphisms with adult-onset Still's disease

SNP	Nearby gene(s)	Chr	Position (hg19)	Risk/non-risk allele	Stage*	RAF in cases	RAF in controls	OR	SE	P values	P_het
rs9268791	HLA-DRA|HLA-DRB5	6	32 421 073	T/C	Meta	–	–	2.363	0.096	4.10E−19	0.686
					Discovery	0.468	0.273	2.389	0.100	2.85E−18
					Replication	0.382	0.224	2.054	0.360	4.54E−02
rs3094178	HLA-G	6	29 818 000	C/G	Meta	–	–	2.139	0.135	1.97E−08	0.806
					Discovery	0.875	0.769	2.116	0.143	1.48E−07
					Replication	0.767	0.568	2.366	0.432	4.62E−02

*The discovery data set comprises 247 cases and 2163 controls from northern and central China. The replication data set comprises 17 cases and 257 controls from southern China.

Chr, chromosome;P_het, p value for heterogeneity test across different cohorts using Cochran's Q test; RAF, frequency of risk allele;SNP, single nucleotide polymorphism.