Table 1.
Gout cases | Controls | p value | OR (95% CI) | |||||||
C/C | C/T | T/T | MAF (%) | C/C | C/T | T/T | MAF (%) | |||
Discovery phase | 447 | 31 | 2 | 3.65 | 427 | 46 | 6 | 6.05 | 0.014 | 0.59 (0.38 to 0.90) |
Replication phase | 859 | 63 | 2 | 3.63 | 1900 | 203 | 5 | 5.02 | 0.015 | 0.71 (0.53 to 0.94) |
Meta-analysis | 7.8×10-4 | 0.67 (0.53 to 0.85) |
In the meta-analysis, no apparent heterogeneity was observed (p value for Cochran's Q test=0.48, I2=0%).
MAF, minor allele frequency.