Table 3.

Univariate and multivariate analysis to predict metastasis

	Univariate analyses			Multivariate analyses
	OR unadjusted	95%CI	P value	OR unadjusted	95%CI	P value
Age > 50 yr	0.95	0.23-4.16	0.942	1.24	0.33-5.2	0.75
Sex (male vs female)	1.25	0.53-2.99	0.617	1.27	0.56-2.91	0.571
N1	2.04	0.53-10.09	0.326	2.27	0.61-10.92	0.251
Tumor size ≥ 3 cm	0.87	0.28-2.8	0.809	1.13	0.4-3.39	0.821
Midkine expression (high-expressed vs low-expressed)	2.12	0.92-5	0.08	1.92	0.87-4.33	0.11
Activin expression (high-expressed vs low-expressed)	1.94	0.78-5.01	0.157	1.62	0.71-3.81	0.261

OR: Odds ratio; HR: Hazard ratio; CI: Confidence interval.