Table 4.

Univariate and multivariate analysis to predict survival

	Univariate analyses			Multivariate analyses
	HR adjusted	95%CI	P value	HR adjusted	95%CI	P value
Age > 50 yrs	2.43	1.18-5.01	0.016	1.9	0.86-4.2	0.113
Sex (male vs female)	0.51	0.34-0.76	0.001	0.66	0.42-1.05	0.078
N1	1.42	0.74-2.73	0.299	1.13	0.54-2.36	0.745
Tumor size ≥ 3 cm	2.13	1.13-4.01	0.02	2.36	1.21-4.62	0.012
Metastases	2.09	1.4-3.12	< 0.001	1.62	1.01-2.62	0.047
Midkine expression (high-expressed vs low-expressed)	1.67	1.12-2.48	0.011	0.76	0.48-1.2	0.24
Activin expression (high-expressed vs low-expressed)	3.61	2.34-5.56	< 0.001	1.98	1.2-3.27	0.008

OR: Odds ratio; HR: Hazard ratio; CI: Confidence interval.