Figure 1. Flowchart of recruitment and data acquisition.

The specific dataset refers to a set of life course data that formed the original criteria for Insight 46 eligibility. See reference 17 for further details. To reach our target sample size, these criteria were relaxed to remove the requirement for a previous measure of lung function, smoking, or physical exercise. ^a In most cases, this was due to erroneous segmentation of vascular abnormalities such as stroke or demyelination. ^b These numbers add up to 54 because some participants had more than one condition. See Methods for details of the definitions of neurologic and psychiatric disorders. FLAIR = fluid-attenuated inversion recovery.