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. 2019 Dec 10;93(24):1056–1066. doi: 10.1212/WNL.0000000000008627

Figure 1. Statins competitively inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting step of cholesterol production.

Figure 1

The majority of the effects of statins are mediated through downregulation of mevalonate and its derivatives.