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. 2019 Dec 10;93(24):e2294–e2305. doi: 10.1212/WNL.0000000000008620

Figure 4. Monocyte chemoattractant protein-1 (MCP-1) correlation to vascular endothelial growth factor (VEGF) secretion and to disease progression.

Figure 4

(A) A significant correlation between VEGF increase and MCP-1 decrease is shown in the CSF of the mesenchymal stem cell (MSC)–neurotrophic factor (NTF) cells treated group at visit six 2 weeks post-transplantation with no significant change in the placebo group. No correlation was seen between VEGF and MCP-1 levels prior to treatment (V5). (B) A significant correlation between MCP-1 in the CSF at 2 weeks post MSC-NTF cells treatment (visit 6, right panel) and a slower disease progression at 12 weeks post-treatment is shown, with no significant change in the placebo group (left panel). ALSFRS-R = Revised ALS Functional Rating Scale.